Recently I need that too !
Your very best possibilities are:
- Do that with C# for example and create a ANE (there are good free libs for that);
- Do that on server-side with C# for example a consume as a webservice;
- Do that with JS (there is a good free lib for that) and load with web view (a modern one via ANE). You can communicate with JS.
I tested both option 2 and 3 successful.
Because I need a lot of communication with business logic, I went thru option 2 but option 3 works very good too.